Volume : 03 Issue : 02
INTERNATIONAL JOURNAL OF DIAGNOSTICS AND RESEARCH [ISSN No.: 2584-2757]
area. This enhanced perfusion aids in the removal
of inflammatory mediators, toxic metabolites, and
cellular waste products, leading to reduction in
pain, swelling, and tissue congestion. Additionally,
the thermal and puncture stimuli are believed to
trigger the release of endogenous opioids such as
endorphins, while also suppressing pain-related
neurotransmitters like Substance P. This dual
mechanism inhibits pain transmission at peripheral,
spinal, and supraspinal levels.[15]From an Ayurvedic
perspective, the ushna (hot) and teekshna (sharp)
qualities of the treatment pacify the vitiated Vata
and Kapha doshas, which are typically involved in
Janusandhigata Vata. This not only alleviates
symptoms such as pain, stiffness, and heaviness,
but also helps reestablish doshic balance at the local
site. Moreover, the heat energy is thought to
stimulate Dhatvagni (metabolic activity at the
tissue level), which assists in digesting Ama
(metabolic toxins) and promoting nourishment of
deeper tissues—especially Asthi (bone) and Majja
(marrow). This contributes to long-term structural
stability of the joint.[17]Pain modulation may also
occur through the gate control mechanism, wherein
edema in periarticular tissues. Muscle relaxation is
another benefit, as the heat helps reduce local
muscle spasms and improves joint biomechanics by
decreasing mechanical stress on the articulating
surfaces.[19,20]Agnikarma
may
stimulate
the
piezoelectric electricity of bone, creating localized
electric signals that encourage deposits in damaged
bone or joint areas, which helps resist deformity,
prevent further damage, and restore normal
function. [17]Reflex and autonomic responses may
also be triggered, such as stimulation of sweat
glands and enhanced systemic detoxification,
contributing to a more holistic therapeutic effect. In
some cases, minor oozing or bleeding at the
puncture site acts as a form of micro-bloodletting,
assisting in the elimination of localized Dushta
Rakta (vitiated blood). [14,18]Over the course of
repeated sessions, the combined mechanical,
thermal, vascular, neural, and metabolic effects of
Viddha-Agnikarma help to "reset" the local joint
environment, breaking the chronic cycle of pain,
immobility, and degeneration.
Probable Mode of Action of Panchatikta Ghrita
Guggulu-[21,22]
the
mechanical
and
thermal
stimulation
Panchatikta
Sandhigata Vata through its combined metabolic,
anti-inflammatory, and tissue-regenerative
Ghrita Guggulu
likely
acts in
preferentially activates non-nociceptive Afibers
which"close the gate" in the dorsal horn of the
spinal
cord,
thereby
reducing
pain
signals
mechanisms. The Tikta Rasa (bitter taste) and
Ushna Virya (hot potency) enhance Dhatvagni
(tissue metabolism), preventing Dhatukshaya—
particularly of Asthi and Majja Dhatus—and
transmitted
by slower-conducting
C-fibers.
Additionally, descending inhibitory pathways from
the brain may be activated, further suppressing
nociceptive transmission and enhancing analgesic
effect.[15,16]The anti-inflammatory properties of
local heat are supported by evidence of reduced
levels of pro-inflammatory mediators such as
prostaglandins and cytokines, along with decreased
promoting tissue nourishment. Its
Pachana (digestive and metabolic) and Lekhana
(scraping) properties reduce Kapha-Meda
Deepana-
accumulation, alleviating stiffness and pain. The
Ghrita base, acting as a Yogavahi, improves
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